Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary diseaseon general respiratory wards

Background- Chronic Obstructive Pulmonary disease (COPD) as defined by Global Initiative for Lung Disease (GOLD) is a common preventable and treatable disease, characterized persistent airflow limitation that usually progressive associated with an enhanced chronic inflammatory response in the airways lung to noxious particles or gases. Objectives-To evaluate outcome of NIV terms ofTime reversion pH normal, Duration NIV, Hospital stay, Failure Mortality compare effect noninvasive mechanical ventilation (NIV) severelyacidotic (pH < 7.25) mildly acidotic 7.25–7.35) patients acute hypercapnic obstructive Methods-This prospective observational study COPD Type 2 respiratory failure initiated on conducted Christian Medical College, Vellore, Tamil Nadu. The was Department Medicine, Vellore.Assuming mean 12h (SD=6h), sample size Hence it decided 25 mild acidosis severe cases this study. In present study, 53 were recruited from April 2017 June 2018.